Decreased serum growth differentiation factor 15 levels after lifestyle intervention in patients with newly diagnosed type 2 diabetes mellitus

Recent studies noted that circulating growth differentiation factor 15 (GDF15) were closely related to metabolic states. Moreover, lifestyle intervention (LI) contributed improvements among patients with diabetes. The study aimed explore the changes of GDF15 levels and their influencing factors after 4 weeks LI or combined breakfast meal replacement (LI + MR) in newly diagnosed type 2 diabetes patients. A total 84 available serum samples at both baseline Week-4 enrolled this biomarker substudy. All subjects underwent a 2-h 75 g oral glucose tolerance test Week-4. Serum determined by sandwich enzyme-linked immunosorbent assay. After LI, overall significantly decreased compared (P < 0.05). ΔGDF15 negatively associated (r = −0.450, P 0.001). optimal cut-off point for predicting decrease was 904.57 pg/mL, an area under curve 0.699. Based on 900 ≥ pg/mL had while those <900 no significant changes. Regression models showed level independent positive improvement fasting plasma homeostasis model assessment insulin resistance only ≥900 pg/mL. led its effect more